\nOnce a toxic agent has distributed into the tissues and organs of the \npatient, the harmful action will continue to persist until an antidote to it \nWill neutralize. Obviously, the use of antidotes is limited, as they do not \nthere are methods to artificially increase metabolic inactivation processes. \nWith filtration, the idea was established that the infusion of greater \namount of fluids in the body should lead not only to the formation of \nmore pee, but also to the removal of toxins. All this has been made \nevident as a result of the forced diuresis of thousands of poisoned people.<\/p>
For \nmost of the drugs taken in overdose, only a small proportion of them \nIs eliminated from the kidney in unchanged form. Usually their action ends \nby metabolic degradation, so diuresis would not change the duration \nof their effects. <\/p>
From \nA therapeutic point of view, forced diuresis can help the patient \npoisoned only when it comes to overdoses of salicylates, barbital and \nphenobarbital, quinine and other amphetamine-like drugs. <\/p>
In addition, \nurine pH can alter the effectiveness of diuresis in excreting the \nmedication.<\/p>
Source: Roy Goulding’s Vademecum of Poisoning Therapy.<\/p>
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