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Correlation between cold sores and Alzheimer’s disease

Herpes_labialis

The herpes simplex virus 1 often alters the face, putting those who are unfortunately affected in an uncomfortable condition. There is a tendency to hide one’s mouth, especially if one is in public places. There is no definitive cure to eradicate the virus from the body, so subsequent to infection you will be subject throughout your life to developing cold sores more or less frequently.

Educate You was among the very first in the country to report the results of an epidemiological study conducted in Taiwan by Dr. Ruth Itzhaki on a possible correlation between the disease of
Alzheimer’s disease
and the herpes simplex 1 virus, the very one responsible for the very annoying bubbles on the lips.

Confirmation now comes from a study conducted on experimental animals by Italian researchers, with Dr. Giovanna De Chiara of the National Research Council in Rome as the first name.

A model of recurrent herpes simplex virus 1 infections in mice that were subjected to repeated cycles of viral reactivation was used in this study. In the course of the study, a spread of the herpes simplex virus 1 also in different brain areas that resulted in the appearance in the brains of animals of some typical features of Alzheimer’s disease, including, most importantly, the protein-beta amyloid constantly present in the brains of people with Alzheimer’s disease. According to the authors, in mice infected with herpes simplex virus 1 The progressive accumulation of typical molecular changes in certain brain areas, including the cortex and hippocampus, correlates with the appearance and increase of cognitive deficits which become irreversible after seven cycles of virus reactivation. The authors conclude that repeated herpes simplex 1 infections could be considered as a risk factor for Alzheimer’s disease.

Source

De Chiara G et al. Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice. PLoS Pathog. 2019 Mar 14;15(3):e1007617. doi: 10.1371/journal.ppat.1007617. eCollection 2019 Mar.

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