The control of insects and similar animals with organophosphorus insecticides is practiced on a large scale. If handled with the due precautions these are not risky for humans. The prototypes of the organophosphorus compounds originated as war gases and can inflict damage permanent to the nervous system. Tri-orthocresyl phosphate is recognized as the responsible for major irreversible and fatal neurological damage in humans. I symptoms initially include headache, asthenia and mental confusion until the onset of vomiting, sweating, hypersalivation, and abdominal pain. Muscle disorders can progress to convulsions, diarrhea, and incontinence urinary.
Diagnosis and treatment
If treatment is to be fast, the diagnosis must be made without hesitation. Confirmation can be obtained by measuring blood cholinesterase levels. Treatment involves complete rest and administration of intramuscular atropine.
Source: Vadecum of poisoning therapy by Roy Goulding
