ARTICOLI CORRELATI

The management of complexity

The Internet offers many insights into the theme of complexity, a web in which one can become bound with no way out. Daily life is characterized by stimuli, problems, unexpected

Children and car travel: preventing boredom

A road trip with children definitely involves ad hoc organization. Think about games to propose, bring along a tablet to entertain him with cartoons and snacks for him to munch on during the trip.

Starting a physical activity: some tips

The reasons that often prompt us to start a physical activity are many and varied. One of the main motivations is definitely aesthetic (one plays sports to improve one’s physical

Quarantine: impact and psychological costs

The Lancet Journal published a very recent review regarding the impact and cost in psychological terms from quarantine. Consideration was given to 24 papers done between 2004 and 2020 in

Stress and well-being

Life is full of setbacks and difficulties; it would be nice to live in an ideal world, but it is not. Every man is constantly confronted with problems, injustices, hardships

New treatment for acute myeloid leukemia

leucemia-mieloide-acuta

Therapy of acute myeloid leukemia

Until 2017, the treatment of acute myeloid leukemia (AML) has always consisted of chemotherapy and bone marrow transplantation. Now available is midostaurin, the first drug that acts specifically only on leukemic cells and is indicated in FMS-like tyrosine kinase 3 (FLT3) mutation carriers, accounting for about one-third of all individuals with AML and the first treatment approved in Italy in 2 years.

Midostaurin is also reimbursed for the treatment of advanced systemic mastocytosis, a rare disease burdened by limited life expectancy with few treatment options. Diagnosis of the FLT3 mutation should be made early because therapy with the specific inhibitor, i.e., midostaurin), should be started as soon as possible (currently it is administered at day 8 after chemotherapy). Follow-ups to assess response to therapy should then be done after induction therapy and at the end of consolidation. It is also important to check with cytofluorimetric and molecular biology tests for residual disease status before and after stem cell transplantation (for patients who will undergo this procedure).

Source: Novartis

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