ARTICOLI CORRELATI

Brain tumor: what to know

Brain tumors do not have typical symptoms because they induce disorders common to many other diseases of the nervous system. These symptoms depend on the size of the tumor and

New blood test detects eight types of cancer

Diagnosing cancer can be complicated and involve unpleasant procedures such as mammograms and colonoscopies; in addition, tumors are often detected only when they have reached a certain size. Researchers are

Bladder cancer: how to prevent it?

Bladder cancer consists of the malignant transformation of the cells lining the inner surface of the bladder itself, i.e., the organ that collects urine filtered by the kidneys before being

Breast cancer, mechanism causes metastasis unveiled

cancro-al-seno-svelato-meccanismo-causa-metastasi

One of the most frequent forms of breast cancer, intraductal breast carcinoma (IDC) represents a commitment for Italian research to seek therapies tailored against carcinoma type.

This type of cancer in 30 percent of cases migrates from its site to affect other organs with metastasis , according to a molecular mechanism found and described in a study published in ‘Nature Materials’ by a team of researchers from the Firc Institute of the University of Milan , and supported by both Airc and the Cariplo Foundation and Miur

The Italian team’s result has made it possible to define a ‘mechanistic signature’ that could allow them to identify the types of neoplasms most at risk of producing metastases, so as to target them with ad hoc treatments.

Intraductal mammary carcinoma (IDC), according to the researchers, is 20% of the most prevalent type of cancer diagnoses, they explain, and is characterized by the occurrence of primary lesions within the mammary duct, which become immobilized due to severe compression by external tissue.

About 70% of the tumor remains ‘solid’ in situ, while the remainder can become fluid’ , managing to exit the breast.

Researcher Giorgio Scita, head of Ifom’s Cancer Cell Research Mechanisms Unit and full professor of General Pathology at State University explains that

“This characteristic makes this type of tumor an ideal model to study the relationship between state transition and the potential for metastasis.”

“Two years ago,” he recalls. we had found that Rab5A, a protein that regulates the ability of cells to internalize membranes and receptors, was surprisingly able to induce fluidization of a tissue of dense, packed epithelial cells. The action is reminiscent of that of a traffic warden who manages to make the congested traffic in our cities flow smoothly. What emerges from our laboratories today is that this motility, observed in a tumor model particularly sensitive to this factor, such as precisely intraductal breast carcinoma, is also associated with the ability of the tumor to modify the extracellular matrix and invade the surrounding tissue.”

We engineered mammary gland cells in such a way as to elevate the level of Rab5A protein, typically highly expressed in the most aggressive breast cancers – report Andrea Palamidessi, Chiara Malinverno and Emanuela Frittoli, the first authors of the work – Thus, we observed that this simple manipulation is sufficient to reawaken the motility of a cell population that had gone into solidification and to allow the acquisition of smooth, flowing collective movements.”.

“The connection between the process regulated by Rab5 and the transition from a more solid state to a more fluid state,” Scita continued. – was explored further using an experimental system consisting of tumor spheroids immersed in a collagen matrix that mimics the microenvironment that our body typically develops to limit tumor growth. Taking advantage of genetic engineering techniques, advanced microscopy and biophysics, tumor cells were observed live to monitor its mode of movement and its ability to modify the collagen fiber network in order to generate channels and escape routes through which to invade the rest of the body.”

“In particular, to study the dynamic characteristics of the tissue and at the same time the forces that the spheroids exert on the matrix in 3D, we developed innovative models and algorithms for the quantitative analysis of the captured footage- point out Fabio Giavazzi, a researcher at Milan State University, and Roberto Cerbino, a professor of applied physics at the university, who also co-signed with Scita the first paper on the Rab5A protein (2017) – Crucial was the use of fluorescent markers that were dispersed in the matrix. It is by following their fluctuations that we were able to obtain information about the tensile forces exerted by the tumor masses on the matrix itself.”.

SPECIALISTI IN EVIDENZA

  • Profile picture of Dott.ssa Floriana Di Martino
    active 3 years, 9 months ago

    Aesthetic Doctors, Basic Doctors

    • Piazza della Rinascita 13 - Pescara
    phone
  • Profile picture of Dr. Antonio Varriale
    active 3 years, 9 months ago

    Aesthetic Doctors, Dentists, Basic Doctors

    • Via Grotta dell Olmo 20 - Giugliano in Campania
    phone
  • Profile picture of Dr. Giuseppe Panico
    active 3 years, 9 months ago

    Dermatologists, Basic Doctors

    • Viale Prassilla 41 - Roma
    phone
  • Profile picture of Dr. Tiziana Volpe
    active 3 years, 9 months ago

    Gynecologists, Basic Doctors, Professional Counselor

    • Piazzale Jonio 50 - Roma
    phone
  • Profile picture of Dr. Sergio Ettore Salteri
    active 3 years, 9 months ago

    Basic Doctors, Chiropractors, Posturologists

    • Via Vial di Romans 8 - Cordenons
    phone

PATOLOGIE CORRELATE

Dyspareunia

Dyspareunia is defined as persistent genital pain that occurs in women shortly before or during intercourse and sometimes still present after intercourse has ended. Painful intercourse can occur for reasons

Hemorrhoids

Hemorrhoids are vascular structures of the anus and lower rectum that serve to maintain fecal continence. If they become swollen or inflamed, they become pathological and cause a syndrome known

Kidney cancer

As with all cancers, the causes of adenocarcinoma and renal sarcomas lie in a series of genetic mutations that allow a group of cells to acquire new characteristics and begin

Urinary incontinence

Urinary incontinence is a condition related to muscular or neurological deficits at the level of the pelvic floor (consisting of the muscle bundles that close the base of the abdomen),

Varicocele

Varicocele is a venous malformation that results from loss of tone and elasticity of the veins that collect blood from the testis and carry it upward into the large venous

Polycystic ovary syndrome

Polycystic ovary syndrome or PCOS (Polycystic ovary syndrome) is a fairly common hormonal disorder among women of childbearing age, so defined because it is related to the presence at the

Cystitis

The term cystitis refers to inflammation of the urinary bladder, in most cases resulting from a bacterial infection. The disorder is especially common among women, who tend to experience it

Benign prostatic hypertrophy

The prostate is a chestnut-shaped gland, several centimeters in diameter, found only in men; it is located in front of the rectum, below the bladder, and surrounds the first part

Ovarian cysts

Ovarian cysts are hollow formations filled with fluid or other materials that may occasionally form within or on the surface of the ovaries at different times in a woman’s life,

Vaginal candidiasis

Vaginal candidiasis is one of the most common causes of genital and vulvar discomfort among women of childbearing age, especially between the ages of 20 and 40. At the origin
CULTURA E SALUTE
 
AGGIORNAMENTI
 
PERCORSI
 

your advertising
exclusively ON
MY SPECIAL DOCTOR

complete the form and you will be contacted by one of our managers