ARTICOLI CORRELATI

Sexual Habits: Outercourse, non-penetrative sex

Sexual partners may move toward outcourse for a variety of reasons of a practical, ideological, moral, or religious nature, to limit the risk of pregnancy, as a matter of sexual preference , as an alternative to menstruation, or for medical impediments that advise against penetration at a given time.

Stroke: here’s what to do

Stroke is a life-threatening emergency. It occurs when a blood vessel in the brain ruptures or becomes obstructed, due to a blood clot. In this case, the brain does not

Daniel Goleman. Emotional intelligence.

“Emotional Intelligence” and “Working with Emotional Intelligence” represent two seminal works for modern psychology; in fact, they resonate as a necessary turning point at a time when we realized the

Sports practice in diabetes and glycemic syndromes

The modern orientation toward physical activity and sports, including competitive sports, in diabetic disease is to no longer consider diabetes as an impediment to experiencing and enjoying sports and exercise.

Alzheimer’s disease: beware of those drugs

memoria

Despite intense research, the causes of Alzheimer ‘s disease continue to be essentially unknown. It has long been believed that mainly two protein factors, ß-amyloid plaques and Tau protein, are involved in its onset. But not all neurologists are convinced of this, and, in any case, it remains to be understood what determines the formation of these toxic substances for brain cells and what is their exact action.

Undoubtedly, the genetic predisposition individual plays an important role in determining the extent and speed of the cognitive decline, but study after study is becoming increasingly clear about the negative contribution of various environmental factors that can interfere with brain cell function and integrity, either directly or indirectly: from substances taken in with food to pollution, from sources of oxidative stress to drugs.

Precisely with regard to the latter, a new call for attention comes from a study conducted by researchers at the University of Nottingham (UK) who investigated the impact on intellectual performance and its age-associated deterioration of anticholinergic active ingredients-a class of drugs comprising molecules used to treat countless clinical conditions and whose use is widespread among the elderly.

They are anticholinergics, e.g., amitriptyline and paroxetine (two commonly used antidepressants), some antipsychotics (quetiapine, olanzapine, chlorpromazine), first-generation antihistamines such as promethazine (used against allergies and sleep disorders), furosemide (a diuretic indicated in cases of hypertension heart failure, and other diseases associated with water retention), amantadine (for the control of Parkinson’s disease), colchicine (prescribed for acute gout attacks), and baclofen (a centrally acting muscle relaxant).

Analyzing the medical records of some 58,800 patients diagnosed with dementia and 255,600 subjects without a diagnosis of dementia (all over the age of 55 and included in British family physician registries), the researchers found a correlation between taking anticholinergic drugs such as those mentioned above and increased risk of developing Alzheimer’s disease.

Specifically, people over 55 who had been chronically using these drugs for more than three years, at the higher dosages or in the “more active” versions, had a 50 percent higher risk of dementia over the next 10 years than those who had never taken them.

Responsible for the largest increase in the risk of Alzheimer’s disease were antipsychotics (+70%), antimuscarinics used against urinary incontinence (+65%), and anti-parkinsonian drugs (+52%), while antidepressants and antiepileptics seem to have a smaller, but still not negligible impact (+30% and +40%, respectively), especially in light of the fact that no effective therapies are currently available against Alzheimer’s disease.

How then to behave? Of course, if an anticholinergic drug is absolutely necessary to treat a significant health problem it must be used. But this need needs to be evaluated with caution, opting for safer alternative therapies whenever possible and, above all, avoiding administering these drugs chronically, over several years, if the benefit obtained is modest and not such as to justify the potential risks to brain health.

Source Coupland CAC et al. Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study. JAMA Intern Med 2019; doi:10.1001/jamainternmed.2019.0677 (https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2736353?widget=personalizedcontent&previousarticle=2736349)

SPECIALISTI IN EVIDENZA

PATOLOGIE CORRELATE

Chronic fatigue syndrome (CFS)

the fatigue syndrome or chronic fatigue (CFS), now also referred to by associating the acronymME/CFS (myalgicencephalomyelitis/chronic fatiguesyndrome), is a rather complex condition that manifests as a condition of intense fatigue

Cerebral aneurysm

A cerebral aneurysm is a vascular malformation that presents as a small spherical protrusion or bulge along the wall of an artery present in the brain. Its presence is risky

Shock, medical emergency

It may happen that the circulation of blood through the body undergoes a sudden change giving rise to a condition of physiological shock, with decreased flow and crisis on the

Neurovegetative dystonia

If you have the patience to interview a family doctor whose outpatient clinic is always very crowded, you will find that a good portion of patients are afflicted with a

Sleep and menopause

Sleep disorders are one of the health problems most often reported by women approaching menopause and in the period after (climacteric). The need for sleep naturally tends to decrease with

Ischemic stroke

According to the official definition of the World Health Organization (WHO), stroke corresponds to a “sudden onset of signs and/or symptoms referable to local and/or global deficits in brain function,

Jet lag

Jet-lag is a sleep disorder that affects those who travel by crossing at least 3-4 time zones, either westward or eastward, due mainly to the temporary failure of synchronization between

Obstructive sleep apnea syndrome

Obstructive sleep apnea is the most prevalent type of sleep apnea: a category of disorders united by the occurrence of repeated interruptions of normal breathing while sleeping, due to a

Uncontrolled eating disorder

Uncontrolled eating disorder is an eating behavior disorder that is characterized by an inability to control food intake, resulting in the more or less frequent repetition of binges similar to

Brain tumors

Brain tumors are rare cancers that can be primary, that is, originate in the brain, or form as secondary metastases of neoplasms in other organs, such as lung or breast
CULTURA E SALUTE
 
AGGIORNAMENTI
 
PERCORSI
 

your advertising
exclusively ON
MY SPECIAL DOCTOR

complete the form and you will be contacted by one of our managers