ARTICOLI CORRELATI

Why psoriasis increases the risk of diabetes

Previous research had already shown that having psoriasis increases the risk of developing type 2 diabetes. A new study from King’s College London has sought to understand why this occurs;

The first white paper on spinal muscular atrophy

Spinalmuscular atrophy (SMA) is one of those rare diseases, moreover chronic, for which treatment is finally looming from a clinical perspective. It affects about 1 in 10,000 infants, is characterized

Shingles: find out more about it

The St. Anthony’s Fire, also called St. Anthony’s rash or Herpes zoster according to scientific nomenclature, is a viral disease that affects individuals who have contracted chickenpox in the past,

Narrative medicine (preview)

Nowadays very often physicians identify patients no longer by their actual name, but by the room number in which they reside and perhaps the condition from which they suffer. It

Why psoriasis increases the risk of diabetes

psoriasi-eritema

Previous research had already shown that having psoriasis increases the risk of developing type 2 diabetes. A new study from King’s College London has sought to understand why this occurs; lead author Elizabeth Evans presented the findings at the recent Society for Endocrinology annual conference held in Glasgow.

British researchers studied human and animal skin samples, looking for any molecular alterations associated with psoriasis that might induce diabetes. In doing so, they identified, in the skin of mice with psoriasis, an inflammatory state and insulin resistance, a known risk factor for diabetes. This resistance means that cells do not respond properly to the hormone insulin and do not remove glucose from the bloodstream. Specifically, fat tissue was seen to absorb glucose less readily, and the researchers measured a reduction in levels of glucose transporter type 4, a receptor needed to move glucose into fat cells. In addition, beta cells in mice with psoriasis produced more insulin than those in unaffected mice: the trial authors believe this overproduction is an attempt to compensate for insulin resistance.

In short, the inflammation associated with psoriasis caused insulin resistance and increased insulin production.

But this is just the beginning of the research: now the team wants to identify which factors released by psoriatic skin may play a role in the development of diabetes. The survey results are expected to improve our understanding of this common skin disease and may also help us better understand diabetes.

Elizabeth Evans said, “If we can discover skin-derived factors that directly influence blood glucose control, we can pave the way for the identification of potential therapeutic targets for the treatment of diabetes or insulin resistance.”

Evans E. et al. Skin-endocrine regulation of whole-body metabolism. Endocrine Abstracts (2018) 59 P102.

https://it.wikipedia.org/wiki/File:Psoriasis_of_the_palms.jpg

SPECIALISTI IN EVIDENZA

  • Profile picture of Dott. Gianlorenzo Casani
    active 3 years, 12 months ago

    Geriatrics, Certifying Doctor, Basic Doctors

    • Via Costantino Baroni 71/73 - Milano
    phone
  • Profile picture of Dr. Squillante Gianni Erminio
    active 3 years, 12 months ago

    Acupuncturists, Homeopathic Medicine, Basic Doctors

    • Via Monterotondo 14 - Roma
    phone
  • Profile picture of Dott. Giovanni Adamo
    active 3 years, 12 months ago

    Angiologists, Basic Doctors

    • Provincia di Ragusa - Ragusa
    phone
  • Profile picture of Dott.ssa Francesca Vittorelli
    active 3 years, 12 months ago

    Therapist, Acupuncturists, Basic Doctors

    • Corso Andrea Palladio 134 - Vicenza
    phone
  • Profile picture of Dott.ssa Emanuela Costantino
    active 3 years, 12 months ago

    • Via Gallinara 2/B - Cagliari
    phone

PATOLOGIE CORRELATE

Intracranial hypertension

Increased pressure within the head box may be related to cerebral edema or the presence of an intracranial expansive lesion, an obstruction of CSF circulation, or the association of these

Gonorrhea

Gonorrhea is one of the most prevalent sexually transmitted diseases (STDs) worldwide, in both sexes, starting as early as adolescence; if not recognized and treated appropriately quickly, it can lead

Ankylosing spondylitis

It can be described as a form of arthritis with inflammation in the spine that causes pain and over time, especially if left untreated, can cause a kind of attachment-fusion

Bronchiectasis

The term “bronchiectasis” refers to a respiratory condition affecting the bronchi that is characterized by the presence of dilatations and degeneration of bronchial tissue, associated with the presence of “mucus

Appendicitis

Appendicitis is an inflammation of the appendix, a tubular formation that is part of the large intestine, which in the past was not given a specific purpose; however, its role

Cerebral aneurysm

A cerebral aneurysm is a vascular malformation that presents as a small spherical protrusion or bulge along the wall of an artery present in the brain. Its presence is risky

Hip fracture

Hip fracture is a serious injury with life-threatening complications. Most hip fractures occur at the femur, the long bone that extends from the pelvis to the knee. The part most

Rheumatoid arthritis

Rheumatoid arthritis is a chronic inflammatory disease on an autoimmune basis that primarily affects the joints, but it affects the entire body and over time, especially if not properly treated,

Hirsutism and virilization

Hirsutism is a condition that primarily affects women and consists of the growth of dark hairs in skin areas in which significant hair is normally present only in adult men,

Colitis

Colitis is an inflammatory bowel disease, which occurs when the lining of the large intestine or colon, and rectum are inflamed. Such inflammation produces small ulcers in the walls of
CULTURA E SALUTE
 
AGGIORNAMENTI
 
PERCORSI
 

your advertising
exclusively ON
MY SPECIAL DOCTOR

complete the form and you will be contacted by one of our managers