Food, sports, sex: easy summer excesses

There are many pleasant and satisfying experiences in the summer in which mood and emotions are at their peak, conditions that could also sometimes cause misjudgment of some hidden dangers in a crescendo of positive and exhilarating experiences. So what ? Spoil the party with negative thoughts and fears ?

Sports disciplines and the risk of shoulder dislocation

The shoulder joint is a mechanism that can provide movement in multiple directions, but precisely because of the versatility of the structure in excursion and mobility, the shoulder also presents an aspect of fragility, being exposed to a continuous risk of injury or dislocation.

We walk half an hour

Good weather encourages outdoor physical activity. If you want to engage inbasic motor activity, such as a simple walk, just devoting a half hour a day, even if every other

Oral candidiasis

Oral candidiasis is aninfection of the mouth caused by a type of fungus called Candida Albicans. It is, therefore, a mycosis that can occur in both men and women of

Customized cardiovascular risk calculators

For more than two decades now, cardiologists have been developing algorithms to calculate the cardiovascular risk, i.e., the probability that a person may be a victim of a heart attack


Rubella is an acute exanthematous infectious disease caused by a RNA virus of the genus Rubivirus of the family Togaviridae. It manifests as a rash similar to those of measles

Lumbago: a psychosomatic symptom?

Talking about psychological factors causing back pain or contributing to its maintenance does not mean that the symptoms are imaginary-they are very real physical problems caused by psychological distress.

Thyroid slowed down?

The thyroid is a small gland that is responsible for regulating metabolism, that is, the rate at which food intake is converted into energy. If thyroid activity slows down too

Cranberry: an aid against antibiotic resistance?


Antibiotic resistance continues to grow globally, and in Italy, the situation is among the most severe in Europe, with many fearsome bacteria now unassailable by most available antibiotics. According to data from theEuropean Center for Diseases Prevention and Control (ECDC), our country accounts for 1/3 of all deaths (10,000 deaths/year) related to antibiotic resistance on the European territory: in the EU/EAA area, a situation of similar severity affects only Greece, Croatia, Bulgaria and Hungary.

In addition to recommending that fewer and better antibiotics be used on the market to preserve their effectiveness and trying to identify new drugs that are more active against bacteria (long, complex, and rarely successful work), researchers are testing the possibility of enhancing the action of current antibiotics or restore their bacteriostatic/bactericidal activity by combining them with other compounds.

Among such strategies that could help overcome the problem is one based on a protein found in the inviting red berries of the cranberry: plant also known as “American cranberry” or “American oxycock” and has long been exploited for its favorable action against inflammation of the female lower urinary tract (in addition to any specific therapy indicated by the doctor).

In particular, a study published in Advance Science indicates that the pro-anthocyanidin protein (c-PAC) contained in cranberry is able to interfere with two important resistance mechanisms developed by pathogenic microorganisms: selective membrane permeability, which allows bacteria to not absorb or to absorb in minimal amounts the antibiotic that should kill them; and active “pumping” outward from the bacterial cell of antibiotic molecules that have already been absorbed, before they can do damage. By reducing the effectiveness of these two defensive mechanisms, c-PAC would have the effect of increasing the response to antibiotics by pathogenic microorganisms.

L’protective effect of c-PAC has been shown in in vitro and in vivo tests on some of the bacteria most dangerous to human health in case of infection and most frequently resistant to available drugs, such as Escherichia coli (mainly responsible for severe and life-threatening gastrointestinal infections, especially in children, the elderly, and people with reduced immune defenses), Pseudomonas aeruginosa (the cause of difficult-to-fight airway, urinary, and eye infections, severe otitis, endocarditis, and often fatal septicemia); and Proteus mirabilis (mainly at the origin of severe urinary tract infections).

In the case of E. coli and P. aeruginosa, c-PAC has been shown not only to prevent the development of tetracycline resistance, but also to reduce the tendency of these bacteria to form biofilms on the surface of target organs. The formation of biofilms, i.e., dense and compact patches of bacteria tightly adhered to mucous membranes and interacting with each other, is a colonization mechanism that microorganisms use to increase their ability to survive, reducing the ability of drugs to attack and kill them. Hindering biofilm formation, therefore, amounts to making bacteria more isolated and fragile.

Whether this initial evidence can be converted into a combination drug containing an antibiotic and the cranberry protein remains to be evaluated, but the avenue opened is certainly interesting and gives cause for hope.


Maisuria VB et al. Proanthocyanidin Interferes with Intrinsic Antibiotic Resistance Mechanisms of Gram-Negative Bacteria. Advance Science 2019; doi:10.1002/advs.201802333 (


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